Pharmacogenomics of cisplatin-induced ototoxicity

[Genetic background of cisplatin induced ototoxicity].

BACKGROUND Cisplatin induced ototoxicity is a serious adverse effect of cisplatin therapy. Cisplatin induced ototoxicity shows significant interindividual variability. This variability is probably based on genetic background. Recent papers describe association of cisplatin ototoxicity with allelic variants of glutathion-S-transferase coding genes. PATIENTS AND METHODS We have analyzed 55 pati...

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants a...

Cisplatin-induced Ototoxicity. Pharmacokinetics, Prediction and Prevention

The use of Maytenus ilicifolia to prevent cisplatin-induced ototoxicity.

UNLABELLED Maytenus ilicifolia is a native plant from South America, with several medicinal properties including antioxidant effects. AIM using an original cisplatin induced ototoxicity model, we evaluated a possible otoprotection caused by Maytenus ilicifolia extract. MATERIALS AND METHODS clinical and experimental study design with female albino guinea pigs divided in groups as follows: 9...

Protective Effect of Minocycline Against Cisplatin-induced Ototoxicity

OBJECTIVES Cisplatin, a widely used chemotherapeutic agent, has serious side effects, including nephrotoxicity and ototoxicity. Minocycline is a semisynthetic second-generation tetracycline that exerts anti-inflammatory and neuroprotective effects. The purpose of this study was to elucidate the protective effect of minocycline against cisplatin-induced ototoxicity in the auditory hair cell. M...